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Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development

MicroRNAs (miRNAs) belong to a class of the endogenously expressed non-coding small RNAs which primarily function as gene regulators. Growing evidence suggests that miRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis. The miR-17...

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Main Authors: Shigoka, Masatoshi (Author) , Tsuchida, Akihiko (Author) , Matsudo, Takaaki (Author) , Nagakawa, Yuichi (Author) , Saito, Hitoshi (Author) , Suzuki, Yoshiaki (Author) , Aoki, Tatsuya (Author) , Murakami, Yoshiki (Author) , Toyoda, Hidenori (Author) , Kumada, Takashi (Author) , Bartenschlager, Ralf (Author) , Kato, Nobuyuki (Author) , Ikeda, Masanori (Author) , Takashina, Tomoki (Author) , Tanaka, Masami (Author) , Suzuki, Rieko (Author) , Oikawa, Kosuke (Author) , Takanashi, Masakatsu (Author) , Kuroda, Masahiko (Author)
Format: Article (Journal)
Language:English
Published: 29 April 2010
In: Pathology international
Year: 2010, Volume: 60, Issue: 5, Pages: 351-357
ISSN:1440-1827
DOI:10.1111/j.1440-1827.2010.02526.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1440-1827.2010.02526.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1827.2010.02526.x
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Author Notes:Masatoshi Shigoka, Akihiko Tsuchida, Takaaki Matsudo, Yuichi Nagakawa, Hitoshi Saito, Yoshiaki Suzuki, Tatsuya Aoki, Yoshiki Murakami, Hidenori Toyoda, Takashi Kumada, Ralf Bartenschlager, Nobuyuki Kato, Masanori Ikeda, Tomoki Takashina, Masami Tanaka, Rieko Suzuki, Kosuke Oikawa, Masakatsu Takanashi and Masahiko Kuroda
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Summary:MicroRNAs (miRNAs) belong to a class of the endogenously expressed non-coding small RNAs which primarily function as gene regulators. Growing evidence suggests that miRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis. The miR-17-92 cluster especially is markedly overexpressed in several cancers, and is associated with the cancer development and progression. In this study, we have demonstrated that miR-92a is highly expressed in hepatocellular carcinoma (HCC). In addition, the proliferation of HCC-derived cell lines was enhanced by miR-92a and inhibited by the anti-miR-92a antagomir. On the other hand, we have found that the relative amount of miR-92a in the plasmas from HCC patients is decreased compared with that from the healthy donors. Interestingly, the amount of miR-92a was elevated after surgical treatment. Thus, although the physiological significance of the decrease of miR-92a in plasma is still unknown, deregulation of miR-92 expression in cells and plasma should be implicated in the development of HCC.
Item Description:Gesehen am 17.07.2023
Physical Description:Online Resource
ISSN:1440-1827
DOI:10.1111/j.1440-1827.2010.02526.x

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