Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
Wnt/beta-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal transmission, notably how the receptors are activated, remains incompletely understood. We found that the prorenin receptor (PRR) is a component of...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 22, 2010
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| In: |
Science
Year: 2010, Volume: 327, Issue: 5964, Pages: 459-463 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.1179802 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.1179802
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| Author Notes: | Cristina-Maria Cruciat, Bisei Ohkawara, Sergio P. Acebron, Emil Karaulanov, Carmen Reinhard, Dierk Ingelfinger, Michael Boutros, Christof Niehrs |
| Summary: | Wnt/beta-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal transmission, notably how the receptors are activated, remains incompletely understood. We found that the prorenin receptor (PRR) is a component of the Wnt receptor complex. PRR functions in a renin-independent manner as an adaptor between Wnt receptors and the vacuolar H+-adenosine triphosphatase (V-ATPase) complex. Moreover, PRR and V-ATPase were required to mediate Wnt signaling during antero-posterior patterning of Xenopus early central nervous system development. The results reveal an unsuspected role for the prorenin receptor, V-ATPase activity, and acidification during Wnt/beta-catenin signaling. |
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| Item Description: | Im Titel ist "+" hochgestellt Gesehen am 19.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.1179802 |