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Desorption kinetics evaluation for the development of validated desorption electrospray ionization-mass spectrometric assays for drug quantification in tissue sections

The development of desorption/ionization (DI) mass spectrometric (MS) assays for drug quantification in tissue sections and their validation according to regulatory guidelines would enable their universalization for applications in (clinical) pharmacology. Recently, new enhancements in desorption el...

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Main Authors: Fresnais, Margaux (Author) , Liang, Siwen (Author) , Seven, Deniz (Author) , Prodanovic, Nevena (Author) , Sundheimer, Julia (Author) , Haefeli, Walter E. (Author) , Burhenne, Jürgen (Author) , Longuespée, Rémi (Author)
Format: Article (Journal)
Language:English
Published: 9 May 2023
In: International journal of molecular sciences
Year: 2023, Volume: 24, Issue: 10, Pages: 1-14
ISSN:1422-0067
DOI:10.3390/ijms24108469
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms24108469
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/24/10/8469
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Author Notes:Margaux Fresnais, Siwen Liang, Deniz Seven, Nevena Prodanovic, Julia Sundheimer, Walter E. Haefeli, Jürgen Burhenne and Rémi Longuespée
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Summary:The development of desorption/ionization (DI) mass spectrometric (MS) assays for drug quantification in tissue sections and their validation according to regulatory guidelines would enable their universalization for applications in (clinical) pharmacology. Recently, new enhancements in desorption electrospray ionization (DESI) have highlighted the reliability of this ion source for the development of targeted quantification methods that meet requirements for method validation. However, it is necessary to consider subtle parameters leading to the success of such method developments, such as the morphology of desorption spots, the analytical time, and sample surface, to cite but a few. Here, we provide additional experimental data highlighting an additional important parameter, based on the unique advantage of DESI-MS on continuous extraction during analysis. ...
Item Description:Gesehen am 30.11.2023
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms24108469

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