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Experimenter familiarization is a crucial prerequisite for assessing behavioral outcomes and reduces stress in mice not only under chronic pain conditions

Rodent behavior is affected by different environmental conditions. These do not only comprise experimental and housing conditions but also familiarization with the experimenter. However, specific effects on pain-related behavior and chronic pain conditions have not been examined. Therefore, we aimed...

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Main Authors: Segelcke, Daniel (Author) , Talbot, Steven R. (Author) , Palme, Rupert (Author) , La Porta, Carmen (Author) , Pogatzki-Zahn, Esther (Author) , Bleich, André (Author) , Tappe-Theodor, Anke (Author)
Format: Article (Journal)
Language:English
Published: 09 February 2023
In: Scientific reports
Year: 2023, Volume: 13, Pages: 1-14
ISSN:2045-2322
DOI:10.1038/s41598-023-29052-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-023-29052-7
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-023-29052-7
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Author Notes:Daniel Segelcke, Steven R. Talbot, Rupert Palme, Carmen La Porta, Esther Pogatzki-Zahn, André Bleich & Anke Tappe-Theodor
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Summary:Rodent behavior is affected by different environmental conditions. These do not only comprise experimental and housing conditions but also familiarization with the experimenter. However, specific effects on pain-related behavior and chronic pain conditions have not been examined. Therefore, we aimed to investigate the impact of different housing conditions, using individually ventilated and standard open top cages, inverted day-night cycles, and experimenter familiarization on male mice following peripheral neuropathy using the spared nerve injury (SNI) model. ...
Item Description:Gesehen am 21.11.2023
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-023-29052-7

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