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Incidence, recurrence, and prevalence of bacterial vaginosis from acute to chronic HIV infection in a prospective cohort of women in South Africa

Purpose - We investigated the incidence, recurrence, prevalence, and risk factors for bacterial vaginosis (BV) diagnosis starting from acute HIV infection among South African women. - Methods - The Centre for the AIDS Programme of Research in South Africa 002 study tested and treated women for BV (N...

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Main Authors: Asare, Kwabena (Author) , Ngcapu, Sinaye (Author) , Osman, Farzana (Author) , Vandormael, Alain (Author) , Mindel, Adrian (Author) , Naicker, Nivashnee (Author) , Khanyile, Mlungisi (Author) , S. Abdool Karim, Salim (Author) , Tomita, Andrew (Author) , Garrett, Nigel (Author)
Format: Article (Journal)
Language:English
Published: June 2023
In: Annals of epidemiology
Year: 2023, Volume: 82, Pages: 33-39
ISSN:1873-2585
DOI:10.1016/j.annepidem.2023.04.004
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.annepidem.2023.04.004
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1047279723000613
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Author Notes:Kwabena Asare, Sinaye Ngcapu, Farzana Osman, Alain Vandormael, Adrian Mindel, Nivashnee Naicker, Mlungisi Khanyile, Salim S. Abdool Karim, Andrew Tomita, Nigel Garrett
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Summary:Purpose - We investigated the incidence, recurrence, prevalence, and risk factors for bacterial vaginosis (BV) diagnosis starting from acute HIV infection among South African women. - Methods - The Centre for the AIDS Programme of Research in South Africa 002 study tested and treated women for BV (Nugent score 7-10) once/twice annually from acute to chronic HIV infection (2004-2020). We estimated BV incidence as the number of new cases and recurrence as the number of subsequent diagnoses per 100 person-years (PYs). We fitted Anderson-Gil Cox-proportional-hazard regression models to determine factors associated with BV incidence or recurrence. - Results - Of 235 participants, the median age at enrollment was 25 years (Inter Quartile Range [IQR] 22-29). BV prevalence at enrollment was 50.6%. BV incidence was 23.9 cases per 100 PYs, and recurrence was 51.3 cases per 100 PYs. BV incidence/recurrence was associated with younger age (<25 years: adjusted hazard ratio [aHR] 1.70, 95% confidence interval [CI] 1.27-2.27), detectable HIV viral load (aHR 1.54, 95% CI 1.27-1.87) and lower CD4 count (<350 cells/μL: aHR 1.33, 95% CI 1.01-1.76). - Conclusions - Our findings underscore the need for early antiretroviral treatment initiation with diagnostic BV and sexually transmitted infection care, especially among younger women.
Item Description:Online verfügbar 8. April 2023, Artikelversion 5. Mai 2023
Gesehen am 21.07.2023
Physical Description:Online Resource
ISSN:1873-2585
DOI:10.1016/j.annepidem.2023.04.004

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