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Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs

SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. Howe...

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Hauptverfasser: Boutin, Sébastien (VerfasserIn) , Hildebrand, Dagmar (VerfasserIn) , Boulant, Steeve (VerfasserIn) , Kreuter, Michael (VerfasserIn) , Rüter, Jule (VerfasserIn) , Pallerla, Srinivas Reddy (VerfasserIn) , Velavan, Thirumalaisamy P. (VerfasserIn) , Nurjadi, Dennis (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 05 July 2021
In: Cellular and molecular life sciences
Year: 2021, Jahrgang: 78, Heft: 16, Pages: 5953-5976
ISSN:1420-9071
DOI:10.1007/s00018-021-03889-5
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00018-021-03889-5
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Verfasserangaben:Sébastien Boutin, Dagmar Hildebrand, Steeve Boulant, Michael Kreuter, Jule Rüter, Srinivas Reddy Pallerla, Thirumalaisamy P. Velavan, Dennis Nurjadi
Beschreibung
Zusammenfassung:SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host’s microbiome and secondary infection which also worsen the disease.
Beschreibung:Gesehen am 21.07.2023
Beschreibung:Online Resource
ISSN:1420-9071
DOI:10.1007/s00018-021-03889-5

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