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Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs

SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. Howe...

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Main Authors: Boutin, Sébastien (Author) , Hildebrand, Dagmar (Author) , Boulant, Steeve (Author) , Kreuter, Michael (Author) , Rüter, Jule (Author) , Pallerla, Srinivas Reddy (Author) , Velavan, Thirumalaisamy P. (Author) , Nurjadi, Dennis (Author)
Format: Article (Journal)
Language:English
Published: 05 July 2021
In: Cellular and molecular life sciences
Year: 2021, Volume: 78, Issue: 16, Pages: 5953-5976
ISSN:1420-9071
DOI:10.1007/s00018-021-03889-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00018-021-03889-5
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Author Notes:Sébastien Boutin, Dagmar Hildebrand, Steeve Boulant, Michael Kreuter, Jule Rüter, Srinivas Reddy Pallerla, Thirumalaisamy P. Velavan, Dennis Nurjadi
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Summary:SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host’s microbiome and secondary infection which also worsen the disease.
Item Description:Gesehen am 21.07.2023
Physical Description:Online Resource
ISSN:1420-9071
DOI:10.1007/s00018-021-03889-5

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