Cover Image

The oral microbiota is a reservoir for antimicrobial resistance: resistome and phenotypic resistance characteristics of oral biofilm in health, caries, and periodontitis

Antimicrobial resistance (AMR) is an ever-growing threat to modern medicine and, according to the latest reports, it causes nearly twice as many deaths globally as AIDS or malaria. Elucidating reservoirs and dissemination routes of antimicrobial resistance genes (ARGs) are essential in fighting AMR....

Full description

Saved in:
Bibliographic Details
Main Authors: Anderson, Annette C. (Author) , von Ohle, C. (Author) , Frese, Cornelia (Author) , Boutin, Sébastien (Author) , Bridson, Calum (Author) , Schoilew, Kyrill (Author) , Peikert, S. A. (Author) , Hellwig, Elmar (Author) , Pelz, K. (Author) , Wittmer, A. (Author) , Wolff, Diana (Author) , Al-Ahmad, Ali (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Annals of clinical microbiology and antimicrobials
Year: 2023, Volume: 22, Pages: 1-19
ISSN:1476-0711
DOI:10.1186/s12941-023-00585-z
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12941-023-00585-z
Get full text
Author Notes:A.C. Anderson, C. von Ohle, C. Frese, S. Boutin, C. Bridson, K. Schoilew, S.A. Peikert, E. Hellwig, K. Pelz, A. Wittmer, D. Wolff and A. Al-Ahmad
Description
Summary:Antimicrobial resistance (AMR) is an ever-growing threat to modern medicine and, according to the latest reports, it causes nearly twice as many deaths globally as AIDS or malaria. Elucidating reservoirs and dissemination routes of antimicrobial resistance genes (ARGs) are essential in fighting AMR. Human commensals represent an important reservoir, which is underexplored for the oral microbiota. Here, we set out to investigate the resistome and phenotypic resistance of oral biofilm microbiota from 179 orally healthy (H), caries active (C), and periodontally diseased (P) individuals (TRN: DRKS00013119, Registration date: 22.10.2022). The samples were analysed using shotgun metagenomic sequencing combined, for the first time, with culture technique. A selection of 997 isolates was tested for resistance to relevant antibiotics.
Item Description:Veröffentlicht: 13. Mai 2023
Gesehen am 25.07.2023
Physical Description:Online Resource
ISSN:1476-0711
DOI:10.1186/s12941-023-00585-z

Similar Items