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Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy

The individual risk of progression of diabetic peripheral neuropathy is difficult to predict for each individual. Mutations in proteins that are responsible for the process of myelination are known to cause neurodegeneration and display alteration in experimental models of diabetic neuropathy. In a...

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Main Authors: Morgenstern, Jakob (Author) , Gröner, Jan (Author) , Jende, Johann (Author) , Kurz, Felix T. (Author) , Strom, Alexander (Author) , Göpfert, Jens Christian (Author) , Kender, Zoltán (Author) , Le Marois, Maxime (Author) , Brune, Maik (Author) , Kuner, Rohini (Author) , Herzig, Stephan (Author) , Roden, Michael (Author) , Ziegler, Dan (Author) , Bendszus, Martin (Author) , Szendrödi, Julia (Author) , Nawroth, Peter Paul (Author) , Kopf, Stefan (Author) , Fleming, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 03 September 2021
In: Diabetologia
Year: 2021, Volume: 64, Issue: 12, Pages: 2843-2855
ISSN:1432-0428
DOI:10.1007/s00125-021-05557-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00125-021-05557-6
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Author Notes:Jakob Morgenstern, Jan B. Groener, Johann M. E. Jende, Felix T. Kurz, Alexander Strom, Jens Göpfert, Zoltan Kender, Maxime Le Marois, Maik Brune, Rohini Kuner, Stephan Herzig, Michael Roden, Dan Ziegler, Martin Bendszus, Julia Szendroedi, Peter Nawroth, Stefan Kopf, Thomas Fleming
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Summary:The individual risk of progression of diabetic peripheral neuropathy is difficult to predict for each individual. Mutations in proteins that are responsible for the process of myelination are known to cause neurodegeneration and display alteration in experimental models of diabetic neuropathy. In a prospective observational human pilot study, we investigated myelin-specific circulating mRNA targets, which have been identified in vitro, for their capacity in the diagnosis and prediction of diabetic neuropathy. The most promising candidate was tested against the recently established biomarker of neural damage, neurofilament light chain protein.
Item Description:Gesehen am 28.07.2023
Physical Description:Online Resource
ISSN:1432-0428
DOI:10.1007/s00125-021-05557-6

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