Cross-phyla protein annotation by structural prediction and alignment
Protein annotation is a major goal in molecular biology, yet experimentally determined knowledge is typically limited to a few model organisms. In non-model species, the sequence-based prediction of gene orthology can be used to infer protein identity; however, this approach loses predictive power a...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 May 2023
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| In: |
Genome biology
Year: 2023, Volume: 24, Pages: 1-21 |
| ISSN: | 1474-760X |
| DOI: | 10.1186/s13059-023-02942-9 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13059-023-02942-9
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| Author Notes: | Fabian Ruperti, Nikolaos Papadopoulos, Jacob M. Musser, Milot Mirdita, Martin Steinegger and Detlev Arendt |
| Summary: | Protein annotation is a major goal in molecular biology, yet experimentally determined knowledge is typically limited to a few model organisms. In non-model species, the sequence-based prediction of gene orthology can be used to infer protein identity; however, this approach loses predictive power at longer evolutionary distances. Here we propose a workflow for protein annotation using structural similarity, exploiting the fact that similar protein structures often reflect homology and are more conserved than protein sequences. |
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| Item Description: | Gesehen am 31.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1474-760X |
| DOI: | 10.1186/s13059-023-02942-9 |