The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus

Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient repre...

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Main Authors: Kaidar-Person, Orit (Author) , Pfob, André (Author) , Gentilini, Oreste Davide (Author) , Borisch, Bettina (Author) , Bosch, Ana (Author) , Cardoso, Maria João (Author) , Curigliano, Giuseppe (Author) , De Boniface, Jana (Author) , Denkert, Carsten (Author) , Hauser, Nik (Author) , Heil, Jörg (Author) , Knauer, Michael (Author) , Kühn, Thorsten (Author) , Lee, Han-Byoel (Author) , Loibl, Sibylle (Author) , Mannhart, Meinrad (Author) , Meattini, Icro (Author) , Montagna, Giacomo (Author) , Pinker, Katja (Author) , Poulakaki, Fiorita (Author) , Rubio, Isabel T. (Author) , Sager, Patrizia (Author) , Steyerova, Petra (Author) , Tausch, Christoph (Author) , Tramm, Trine (Author) , Vrancken Peeters, Marie-Jeanne (Author) , Wyld, Lynda (Author) , Yu, Jong Han (Author) , Weber, Walter Paul (Author) , Poortmans, Philip (Author) , Dubsky, Peter (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: EClinicalMedicine
Year: 2023, Volume: 61, Pages: 1-13
ISSN:2589-5370
DOI:10.1016/j.eclinm.2023.102085
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.eclinm.2023.102085
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2589537023002626
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Author Notes:Orit Kaidar-Person, André Pfob, Oreste Davide Gentilini, Bettina Borisch, Ana Bosch, Maria João Cardoso, Giuseppe Curigliano, Jana De Boniface, Carsten Denkert, Nik Hauser, Jörg Heil, Michael Knauer, Thorsten Kühn, Han-Byoel Lee, Sibylle Loibl, Meinrad Mannhart, Icro Meattini, Giacomo Montagna, Katja Pinker, Fiorita Poulakaki, Isabel T. Rubio, Patrizia Sager, Petra Steyerova, Christoph Tausch, Trine Tramm, Marie-Jeanne Vrancken Peeters, Lynda Wyld, Jong Han Yu, Walter Paul Weber, Philip Poortmans, Peter Dubsky
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Summary:Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient representatives, addresses the challenges of clinical axillary lymph node management, from diagnosis to local therapy of the axilla. Five working packages were developed, following the patients’ journey and addressing specific clinical scenarios. Panellists voted on 72 statements, reaching consensus (agreement of 75% or more) in 52.8%, majority (51%-74% agreement) in 43.1%, and no decision in 4.2%. Based on the votes, targeted imaging and standardized pathology of lymph nodes should be a prerequisite to planning local and systemic therapy, axillary lymph node dissection can be replaced by sentinel lymph node biopsy ( ± targeted approaches) in a majority of scenarios; and positive patient outcomes should be driven by both low recurrence risks and low rates of lymphoedema.
Item Description:Gesehen am 01.08.2023
Physical Description:Online Resource
ISSN:2589-5370
DOI:10.1016/j.eclinm.2023.102085