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Mechano-redox control of Mac-1 de-adhesion by PDI promotes directional movement under flow

Neutrophil migration is critical to the initiation and resolution of inflammation. Macrophage-1 antigen (Mac-1; CD11b/CD18, αMβ2) is a leukocyte integrin essential for firm adhesion to endothelial ICAM-1 (intercellular adhesion molecule 1) and migration of neutrophils in the shear forces of the circ...

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Main Authors: DuPuy-Montbrun, Alexandre (Author) , Aponte-Santamaria, Camilo (Author) , Yeheskel, Adva (Author) , Hortle, Elinor (Author) , Oehlers, Stefan H. (Author) , Gräter, Frauke (Author) , Hogg, Philip J. (Author) , Passam, Freda H. (Author) , Chiu, Joyce (Author)
Format: Article (Journal)
Language:English
Published: April 28, 2023
In: Circulation research
Year: 2023, Volume: 132, Issue: 9, Pages: e151-e168
ISSN:1524-4571
DOI:10.1161/CIRCRESAHA.122.321926
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCRESAHA.122.321926
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321926
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Author Notes:Alexander Dupuy, Camilo Aponte-Santamaría, Adva Yeheskel, Elinor Hortle, Stefan H. Oehlers, Frauke Gräter, Philip J. Hogg, Freda H. Passam, Joyce Chiu
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Summary:Neutrophil migration is critical to the initiation and resolution of inflammation. Macrophage-1 antigen (Mac-1; CD11b/CD18, αMβ2) is a leukocyte integrin essential for firm adhesion to endothelial ICAM-1 (intercellular adhesion molecule 1) and migration of neutrophils in the shear forces of the circulation. PDI (protein disulfide isomerase) has been reported to influence neutrophil adhesion and migration. We aimed to elucidate the molecular mechanism of PDI control of Mac-1 affinity for ICAM-1 during neutrophil migration under fluid shear.
Item Description:Online veröffentlicht am 6. April 2023
Gesehen am 05.12.2023
Physical Description:Online Resource
ISSN:1524-4571
DOI:10.1161/CIRCRESAHA.122.321926

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