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Polysaccharides from Sargassum tenerrimum: structural features, chemical modification and anti-viral activity

Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. Here, we exploit an approach to inhibiting HSV infection by using a sulfated fucoidan, and a guluronic acid-rich alginate derived from Sargassum tenerrimum, mimicki...

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Main Authors: Sinha, Sharmistha (Author) , Astani, Akram (Author) , Ghosh, Tuhin (Author) , Schnitzler, Paul (Author) , Ray, Bimalendu (Author)
Format: Article (Journal)
Language:English
Published: 2010 Feb
In: Phytochemistry
Year: 2010, Volume: 71, Issue: 2, Pages: 235-242
ISSN:1873-3700
DOI:10.1016/j.phytochem.2009.10.014
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.phytochem.2009.10.014
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0031942209004531
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Author Notes:Sharmistha Sinha, Akram Astani, Tuhin Ghosh, Paul Schnitzler, Bimalendu Ray
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Summary:Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. Here, we exploit an approach to inhibiting HSV infection by using a sulfated fucoidan, and a guluronic acid-rich alginate derived from Sargassum tenerrimum, mimicking the active domain of the entry receptor. These macromolecules have apparent molecular masses of 30±5 and 26±5kDa, respectively. They and their chemically sulfated derivatives showed activity against herpes simplex virus type 1 (HSV-1). Their inhibitory concentration 50% (IC50) values were in the range 0.5-15μg/ml and they lacked cytotoxicity at concentrations up to 1000μg/ml. The anti-HSV activity increased with increasing sulfate ester content. Our results suggest the feasibility of inhibiting HSV infection by blocking viral entry with polysaccharide having specific structure.
Item Description:Gesehen am 02.08.2023
Physical Description:Online Resource
ISSN:1873-3700
DOI:10.1016/j.phytochem.2009.10.014

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