Polysaccharides from Sargassum tenerrimum: structural features, chemical modification and anti-viral activity
Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. Here, we exploit an approach to inhibiting HSV infection by using a sulfated fucoidan, and a guluronic acid-rich alginate derived from Sargassum tenerrimum, mimicki...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010 Feb
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| In: |
Phytochemistry
Year: 2010, Jahrgang: 71, Heft: 2, Pages: 235-242 |
| ISSN: | 1873-3700 |
| DOI: | 10.1016/j.phytochem.2009.10.014 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.phytochem.2009.10.014 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0031942209004531 
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| Verfasserangaben: | Sharmistha Sinha, Akram Astani, Tuhin Ghosh, Paul Schnitzler, Bimalendu Ray |
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| 520 | |a Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. Here, we exploit an approach to inhibiting HSV infection by using a sulfated fucoidan, and a guluronic acid-rich alginate derived from Sargassum tenerrimum, mimicking the active domain of the entry receptor. These macromolecules have apparent molecular masses of 30±5 and 26±5kDa, respectively. They and their chemically sulfated derivatives showed activity against herpes simplex virus type 1 (HSV-1). Their inhibitory concentration 50% (IC50) values were in the range 0.5-15μg/ml and they lacked cytotoxicity at concentrations up to 1000μg/ml. The anti-HSV activity increased with increasing sulfate ester content. Our results suggest the feasibility of inhibiting HSV infection by blocking viral entry with polysaccharide having specific structure. | ||
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