Combined proteomics and CRISPR-Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells.

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Bibliographic Details
Main Authors:	Bahrami, Ehsan (Author) , Schmid, Jan Philipp (Author) , Jurinovic, Vindi (Author) , Becker, Martin (Author) , Wirth, Anna-Katharina (Author) , Ludwig, Romina (Author) , Kreissig, Sophie (Author) , Duque Angel, Tania Vanessa (Author) , Amend, Diana (Author) , Hunt, Katharina (Author) , Öllinger, Rupert (Author) , Rad, Roland (Author) , Frenz, Joris (Author) , Solovey, Maria (Author) , Ziemann, Frank (Author) , Mann, Matthias (Author) , Vick, Binje (Author) , Wichmann, Christian (Author) , Herold, Tobias (Author) , Jayavelu, Ashok Kumar (Author) , Jeremias, Irmela (Author)
Format:	Article (Journal)
Language:	English
Published:	2023
In:	Molecular cancer Year: 2023, Volume: 22, Pages: 1-19
ISSN:	1476-4598
DOI:	10.1186/s12943-023-01803-0
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12943-023-01803-0
Author Notes:	Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu and Irmela Jeremias

Description
Summary:	Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells.
Item Description:	Veröffentlicht: 08 July 2023 Gesehen am 03.08.2023
Physical Description:	Online Resource
ISSN:	1476-4598
DOI:	10.1186/s12943-023-01803-0