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Different profiles of cytokine expression during mild and severe acute pancreatitis

AIM: To study secretion patterns of pro- and anti-inflammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood. - METHODS: We have conducted a prospective observational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of t...

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Main Authors: Dambrauskas, Zilvinas (Author) , Giese, Nathalia (Author) , Gulbinas, Antanas (Author) , Giese, Thomas (Author) , Berberat, Pascal O. (Author) , Pundzius, Juozas (Author) , Barauskas, Giedrius (Author) , Friess, Helmut (Author)
Format: Article (Journal)
Language:English
Published: 21 April 2010
In: World journal of gastroenterology
Year: 2010, Volume: 16, Issue: 15, Pages: 1845-1853
ISSN:2219-2840
DOI:10.3748/wjg.v16.i15.1845
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3748/wjg.v16.i15.1845
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Author Notes:Zilvinas Dambrauskas, Nathalia Giese, Antanas Gulbinas, Thomas Giese, Pascal O. Berberat, Juozas Pundzius, Giedrius Barauskas, Helmut Friess
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Summary:AIM: To study secretion patterns of pro- and anti-inflammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood. - METHODS: We have conducted a prospective observational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of the disease within last 72 h were included in this study. The mRNA expression of 25 different types of cytokines in white blood cells was determined by quantitative real time polymerase chain reaction. Levels of 8 different cytokines in blood serum were measured by enzyme linked immunosorbent assay. Clinical data and cytokine expression results were subjected to statistical analysis. - RESULTS: Severe and necrotizing acute pancreatitis (AP) is characterized by the significant depletion of circulating lymphocytes. Severe acute pancreatitis is associated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cytokines [interleukin (IL)-6, IL-8, macrophage migration inhibitory factor (MIF)]. Serum IL-6 and MIF concentrations are the best discriminators of severe and necrotizing AP as well as possible fatal outcome during the early course of the disease. - CONCLUSION: Deregulation of cellular immune system is a key event leading to severe and necrotizing AP. IL-6 and MIF could be used as early predictors of complications.
Item Description:Gesehen am 03.08.2023
Physical Description:Online Resource
ISSN:2219-2840
DOI:10.3748/wjg.v16.i15.1845

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