Different profiles of cytokine expression during mild and severe acute pancreatitis
AIM: To study secretion patterns of pro- and anti-inflammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood. - METHODS: We have conducted a prospective observational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of t...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 April 2010
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| In: |
World journal of gastroenterology
Year: 2010, Jahrgang: 16, Heft: 15, Pages: 1845-1853 |
| ISSN: | 2219-2840 |
| DOI: | 10.3748/wjg.v16.i15.1845 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3748/wjg.v16.i15.1845
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| Verfasserangaben: | Zilvinas Dambrauskas, Nathalia Giese, Antanas Gulbinas, Thomas Giese, Pascal O. Berberat, Juozas Pundzius, Giedrius Barauskas, Helmut Friess |
| Zusammenfassung: | AIM: To study secretion patterns of pro- and anti-inflammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood. - METHODS: We have conducted a prospective observational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of the disease within last 72 h were included in this study. The mRNA expression of 25 different types of cytokines in white blood cells was determined by quantitative real time polymerase chain reaction. Levels of 8 different cytokines in blood serum were measured by enzyme linked immunosorbent assay. Clinical data and cytokine expression results were subjected to statistical analysis. - RESULTS: Severe and necrotizing acute pancreatitis (AP) is characterized by the significant depletion of circulating lymphocytes. Severe acute pancreatitis is associated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cytokines [interleukin (IL)-6, IL-8, macrophage migration inhibitory factor (MIF)]. Serum IL-6 and MIF concentrations are the best discriminators of severe and necrotizing AP as well as possible fatal outcome during the early course of the disease. - CONCLUSION: Deregulation of cellular immune system is a key event leading to severe and necrotizing AP. IL-6 and MIF could be used as early predictors of complications. |
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| Beschreibung: | Gesehen am 03.08.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 2219-2840 |
| DOI: | 10.3748/wjg.v16.i15.1845 |