Early breast cancer precursor lesions: lessons learned from molecular and clinical studies
Atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), and lobular neoplasia (LN) form a group of early precursor lesions that are part of the low-grade pathway in breast cancer development. This concept implies that the neoplastic disease process begins at a stage much earlier than in sit...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 23, 2010
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| In: |
Breast care
Year: 2010, Volume: 5, Issue: 4, Pages: 218-226 |
| ISSN: | 1661-3805 |
| Online Access: |
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| Author Notes: | Hans-Peter Sinn, Zeinab Elsawaf, Birgit Helmchen, Sebastian Aulmann |
| Summary: | Atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), and lobular neoplasia (LN) form a group of early precursor lesions that are part of the low-grade pathway in breast cancer development. This concept implies that the neoplastic disease process begins at a stage much earlier than in situ carcinoma. We have performed a review of the published literature for the upgrade risk to ductal carcinoma in situ or invasive carcinoma in open biopsy after a diagnosis of ADH, FEA, or LN in core needle biopsy. This has revealed the highest upgrade risk for ADH (28.2% after open biopsy), followed by LN (14.9%), and FEA (10.2%). With LN, the pleomorphic subtype is believed to confer a higher risk than classical LN. With all types of precursor lesions, careful attention must be paid to the clinicopathological correlation for the guidance of the clinical management. Follow-up biopsies are generally indicated in ADH, and if there is any radiological-pathological discrepancy, also in LN or FEA. |
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| Item Description: | Gesehen am 03.08.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1661-3805 |