Distribution and detectability of EGFR exon 20 insertion variants in NSCLC
EGFR exon 20 insertion (ex20ins) mutations represent 5% to 10% of EGFR mutations in NSCLC. Identifying patients with EGFR ex20ins is challenging owing to the limited coverage of polymerase chain reaction (PCR) assays and the relatively recent use of next-generation sequencing (NGS). This study analy...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2023
|
| In: |
Journal of thoracic oncology
Year: 2023, Volume: 18, Issue: 6, Pages: 744-754 |
| ISSN: | 1556-1380 |
| DOI: | 10.1016/j.jtho.2023.01.086 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jtho.2023.01.086 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1556086423000953 
|
| Author Notes: | Sai-Hong Ignatius Ou, MD, PhD, Jin-Liern Hong, PhD, Petros Christopoulos, MD, PhD, Huamao M. Lin, PhD, Sylvie Vincent, PhD, Eric N. Churchill, PhD, Junpei Soeda, MD, PhD, Daniel Kazdal, PhD, Albrecht Stenzinger, MD, Michael Thomas, MD |
| Summary: | EGFR exon 20 insertion (ex20ins) mutations represent 5% to 10% of EGFR mutations in NSCLC. Identifying patients with EGFR ex20ins is challenging owing to the limited coverage of polymerase chain reaction (PCR) assays and the relatively recent use of next-generation sequencing (NGS). This study analyzes the spectrum of EGFR ex20ins variants in a large patient population from a global clinical trial and several real-world cohorts and the ability of PCR kits to identify these alterations. |
|---|---|
| Item Description: | Online veröffentlicht am 3. Februar 2023 Gesehen am 06.12.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1556-1380 |
| DOI: | 10.1016/j.jtho.2023.01.086 |