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Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study using linear and Co...

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Main Authors: Moissl-Blanke, Angela P. (Author) , Lorkowski, Stefan (Author) , Meinitzer, Andreas (Author) , Pilz, Stefan (Author) , Scharnagl, Hubert (Author) , Delgado Gonzales de Kleber, Graciela (Author) , Kleber, Marcus E. (Author) , Krämer, Bernhard (Author) , Pieske, Burkert (Author) , Grübler, Martin R. (Author) , Brussee, Helmut (Author) , von Lewinski, Dirk (Author) , Toplak, Hermann (Author) , Fahrleitner-Pammer, Astrid (Author) , März, Winfried (Author) , Tomaschitz, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 21 April 2023
In: iScience
Year: 2023, Volume: 26, Issue: 4, Pages: 1-20
ISSN:2589-0042
DOI:10.1016/j.isci.2023.106459
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.isci.2023.106459
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2589004223005369
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Author Notes:Angela P. Moissl, Stefan Lorkowski, Andreas Meinitzer, Stefan Pilz, Hubert Scharnagl, Graciela E. Delgado, Marcus E. Kleber, Bernhard K. Krämer, Burkert Pieske, Martin R. Grübler, Helmut Brussee, Dirk von Lewinski, Hermann Toplak, Astrid Fahrleitner-Pammer, Winfried März, and Andreas Tomaschitz
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Summary:Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study using linear and Cox regression. Adiponectin, hemoglobin, C-peptide, hemoglobin A1c, and homoarginine showed the strongest association with BCAA concentration (all p < 0.001). During a median follow-up of 10.5 years, 715 participants died, including 450 cardiovascular-related deaths. BCAA concentrations were inversely associated with the risk of all-cause and cardiovascular mortality (HR [95% CI] per 1-SD increase in log-BCAA: 0.75 [0.69-0.82] and 0.72 [0.65-0.80], respectively) after adjustment for potential confounders. BCAAs are directly associated with metabolic risk but inversely with mortality in persons with intermediate-to-high cardiovascular risk. Further studies are warranted to evaluate the diagnostic and therapeutic utility of BCAA in the context of cardiovascular diseases.
Item Description:Online verfügbar: 21. März 2023, Artikelversion: 31. März 2023
Gesehen am 04.08.2023
Physical Description:Online Resource
ISSN:2589-0042
DOI:10.1016/j.isci.2023.106459

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