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Analysis of de novo donor-specific HLA-DPB1 antibodies in kidney transplantation

HLA matching and avoidance of unacceptable mismatches are important aspects in the selection of donors for solid organ transplantation. The impact of HLA-DPB1 incompatibility on the outcomes of kidney transplantation is not fully understood. We investigated a potential effect of mismatching for HLA-...

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Main Authors: Tang, Chen (Author) , Unterrainer, Christian (Author) , Fink, Annette (Author) , Cinca, Sofia (Author) , Ruhenstroth, Andrea (Author) , Scherer, Sabine (Author) , Morath, Christian (Author) , Zeier, Martin (Author) , Mehrabi, Arianeb (Author) , Süsal, Caner (Author) , Tran, Thuong Hien (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: HLA
Year: 2021, Volume: 98, Issue: 5, Pages: 423-430
ISSN:2059-2310
DOI:10.1111/tan.14422
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/tan.14422
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.14422
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Author Notes:Chen Tang, Christian Unterrainer, Annette Fink, Sofia Cinca, Andrea Ruhenstroth, Sabine Scherer, Christian Morath, Martin Zeier, Arianeb Mehrabi, Caner Süsal, Thuong Hien Tran
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Summary:HLA matching and avoidance of unacceptable mismatches are important aspects in the selection of donors for solid organ transplantation. The impact of HLA-DPB1 incompatibility on the outcomes of kidney transplantation is not fully understood. We investigated a potential effect of mismatching for HLA-DPB1 at allele, eplet, or Terasaki epitope (TerEp) level on the formation of de novo donor-specific antibodies (dnDSA) and also asked whether polymorphisms associated with HLA-DPB1 expression level may influence dnDSA induction. Furthermore, we analyzed the correlation between graft survival and HLA-DPB1 mismatches defined by different approaches. A cohort of 366 patients who received a kidney transplant at the Heidelberg University Hospital, Germany, with availability of pre- and post-transplant HLA antibody results by single antigen testing as well as of donor and recipient HLA-DPB1 high-resolution typing were analyzed retrospectively. Susceptibility to increased HLA-DPB1 expression was predicted by the linked dimorphism rs9277534 A/G of the HLA-DPB1 gene. Neither HLA-DPB1 mismatches at allele, eplet or TerEp level nor exposure to donor's high HLA-DPB1 expression were significantly associated with the risk of developing dnDSA against HLA-DPB1. However, HLA-DPB1 eplet and TerEp mismatches had a significant negative impact on graft survival (p < 0.001 and p = 0.003, respectively). Matching for HLA-DPB1 at epitope instead of allele level appears to have potential to improve graft survival in kidney transplantation.
Item Description:Gesehen am 08.08.2023
Physical Description:Online Resource
ISSN:2059-2310
DOI:10.1111/tan.14422

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