Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso
In 111 children under five years of age and with uncomplicated malaria in Nouna, north-western Burkina Faso, amodiaquine treatment failed in 75% (after PCR-based exclusion of new infections, 32%). In these, we assessed the role of Plasmodium falciparum pfmdr1 and pfcrt polymorphisms in amodiaquine r...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
7 January 2010
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| In: |
Acta tropica
Year: 2010, Volume: 114, Issue: 1, Pages: 63-66 |
| ISSN: | 1873-6254 |
| DOI: | 10.1016/j.actatropica.2009.12.008 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.actatropica.2009.12.008 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0001706X10000021 
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| Author Notes: | Ina Danquah, Boubacar Coulibaly, Peter Meissner, Inga Petruschke, Olaf Müller, Frank P. Mockenhaupt |
| Summary: | In 111 children under five years of age and with uncomplicated malaria in Nouna, north-western Burkina Faso, amodiaquine treatment failed in 75% (after PCR-based exclusion of new infections, 32%). In these, we assessed the role of Plasmodium falciparum pfmdr1 and pfcrt polymorphisms in amodiaquine resistance. Except for pfmdr1 1246Y (prevalence, 5%), no P. falciparum allele predicted treatment outcome. Pfcrt 76T as well as pfmdr1 86Y, 86Y-184F-1246D, and 86Y-184Y-1246Y were positively selected in treatment failures, and pfmdr1 86N-184F-1246D negatively. The weak association of pfmdr1/pfcrt alleles with amodiaquine treatment outcome suggests further factors to be involved in the unsatisfactory low efficacy of the drug and limits the usefulness of these markers in this area. |
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| Item Description: | Gesehen am 10.08.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1873-6254 |
| DOI: | 10.1016/j.actatropica.2009.12.008 |