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Diabetic neuropathy is a generalized phenomenon with impact on hand functional performance and quality of life

Background and purpose Diabetic sensorimotor peripheral neuropathy is usually considered to affect predominantly the lower limbs (LL-N), whereas the impact of upper limb neuropathy (UL-N) on hand functional performance and quality of life (QoL) has not been evaluated systematically. This study aims...

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Main Authors: Kender, Zoltán (Author) , Gröner, Jan (Author) , Jende, Johann (Author) , Kurz, Felix T. (Author) , Fleming, Thomas (Author) , Sulaj, Alba (Author) , Schuh-Hofer, Sigrid (Author) , Treede, Rolf-Detlef (Author) , Bendszus, Martin (Author) , Szendrödi, Julia (Author) , Nawroth, Peter Paul (Author) , Kopf, Stefan (Author)
Format: Article (Journal)
Language:English
Published: October 2022
In: European journal of neurology
Year: 2022, Volume: 29, Issue: 10, Pages: 3081-3091
ISSN:1468-1331
DOI:10.1111/ene.15446
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ene.15446
Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/ene.15446
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Author Notes:Zoltan Kender, Jan B. Groener, Johann M.E. Jende, Felix T. Kurz, Thomas Fleming, Alba Sulaj, Sigrid Schuh-Hofer, Rolf-Detlef Treede, Martin Bendszus, Julia Szendroedi, Peter P. Nawroth, Stefan Kopf
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Summary:Background and purpose Diabetic sensorimotor peripheral neuropathy is usually considered to affect predominantly the lower limbs (LL-N), whereas the impact of upper limb neuropathy (UL-N) on hand functional performance and quality of life (QoL) has not been evaluated systematically. This study aims to investigate the prevalence and characteristics of UL-N and its functional and psychosocial consequences in type 2 diabetes. Methods Individuals with type 2 diabetes (n = 141) and an age- and sex-matched control group (n = 73) underwent comprehensive assessment of neuropathy, hand functional performance, and psychosocial status. Results The prevalence of UL-N was 30.5% in patients with diabetes and that of LL-N was 49.6%, with 25.5% exhibiting both. Patients with diabetes showed similar sensory phenotype regarding both large and small fiber functions in hands and feet. Patients with UL-N showed reduced manual dexterity, but normal hand grip force. Additionally, there was a correlation between reduced dexterity and sensory deficits. Patients with UL-N had reduced estimates of psychosocial health including health-related QoL compared to control subjects and patients without UL-N. UL-N correlated with the severity of LL-N, but not with duration of diabetes, glycemia, age, or sex. Conclusions This study points to a substantial prevalence of UL-N in type 2 diabetes. The sensory phenotype of patients with UL-N was similar to LL-N and was characterized by loss of sensory function. Our study demonstrated an association of UL-N with impaired manual dexterity and reduced health-related QoL. Thus, upper limb sensorimotor functions should be assessed early in patients with diabetes.
Item Description:Online veröffentlicht: 14. Juni 2022
Gesehen am 14.08.2023
Physical Description:Online Resource
ISSN:1468-1331
DOI:10.1111/ene.15446

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