Cover Image

The role of claudin-6 in chromophobe renal cell carcinoma

Background. The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear. Aim. To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC). Material and Methods. Patients who underwent renal surgery due to chRCC were r...

Full description

Saved in:
Bibliographic Details
Main Authors: Erlmeier, Franziska (Author) , Zschäbitz, Stefanie (Author) , Mikuteit, Marie (Author) , Autenrieth, Michael (Author) , Weichert, Wilko (Author) , Hartmann, Arndt (Author) , Steffens, Sandra (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Histology and histopathology
Year: 2023, Volume: 38, Issue: 4, Pages: 403-407
ISSN:1699-5848
DOI:10.14670/HH-18-520
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.14670/HH-18-520
Verlag, kostenfrei, Volltext: https://www.hh.um.es/Abstracts/Vol_38/38_4/38_4_403.htm
Get full text
Author Notes:Franziska Erlmeier, Stefanie Zschaebitz, Marie Mikuteit, Michael Autenrieth, Wilko Weichert, Arndt Hartmann and Sandra Steffens
Description
Summary:Background. The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear. Aim. To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC). Material and Methods. Patients who underwent renal surgery due to chRCC were recruited. Clinical data were retrospectively evaluated. Tumor specimens were analyzed for CLDN6 expression by immunohisto-chemistry. Results. 81 chRCC patients were eligible for analysis, thereof 10 (12.3%) patients were positive for CLDN6. No significant associations were found for CLDN6 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in overall survival (OS) for patients with CLDN6- compared to CLDN6+ tumors (87.0% versus 62.5%; p=0.174). Conclusion. In chRCC CLDN6 expression is not associated with parameters of aggressiveness or survival. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.
Item Description:Gesehen am 14.08.2023
Physical Description:Online Resource
ISSN:1699-5848
DOI:10.14670/HH-18-520

Similar Items