Fatal chloroquine intoxication
A suicidal ingestion of an unknown quantity of Resochin® (chloroquine) tablets is described. Although chloroquine is known since 1934, intoxications due to chloroquine overdose are rather rare in European countries. The authors report on a new and fast method of analysing and determining the chloroq...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 September 1998
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| In: |
Forensic science international
Year: 1998, Volume: 96, Issue: 1, Pages: 21-28 |
| ISSN: | 1872-6283 |
| DOI: | 10.1016/S0379-0738(98)00105-4 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0379-0738(98)00105-4 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0379073898001054 
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| Author Notes: | Thomas Keller, Andrea Schneider, Robert Lamprecht, Rolf Aderjan, Edith Tutsch-Bauer, Wolfgang Kisser |
| Summary: | A suicidal ingestion of an unknown quantity of Resochin® (chloroquine) tablets is described. Although chloroquine is known since 1934, intoxications due to chloroquine overdose are rather rare in European countries. The authors report on a new and fast method of analysing and determining the chloroquine concentration in body fluids and postmortem specimens. The analytes were extracted from alkalinized samples into ethyl acetate before GC/MS analysis. The analyses of chloroquine were performed without any complex sample clean-up steps and, in addition, with little sample material. The proposed method resulted in a rapid procedure most useful in cases of deliberate poisoning with the anti-inflammatory and antimalarial drug chloroquine. |
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| Item Description: | Gesehen am 15.08.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1872-6283 |
| DOI: | 10.1016/S0379-0738(98)00105-4 |