Mdm2-SUMO1: is bigger better?
Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 2000
|
| In: |
Nature cell biology
Year: 2000, Volume: 2, Issue: 9, Pages: E161-E163 |
| ISSN: | 1476-4679 |
| DOI: | 10.1038/35023639 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/35023639 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncb0900_E161 
|
| Author Notes: | Frauke Melchior and Ludger Hengst |
| Summary: | Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. |
|---|---|
| Item Description: | Gesehen am 17.08.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1476-4679 |
| DOI: | 10.1038/35023639 |