SUMO: ligases, isopeptidases and nuclear pores
Small ubiquitin-related modifier (SUMO) proteins are reversibly coupled to numerous intracellular targets and modulate their interactions, localization, activity or stability. Recent advances in the SUMO field have uncovered the first SUMO E3 ligases and point to a complex family of isopeptidases. S...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 2003
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| In: |
Trends in biochemical sciences
Year: 2003, Volume: 28, Issue: 11, Pages: 612-618 |
| ISSN: | 1362-4326 |
| DOI: | 10.1016/j.tibs.2003.09.002 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tibs.2003.09.002 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0968000403002263 
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| Author Notes: | Frauke Melchior, Marion Schergaut, Andrea Pichler |
| Summary: | Small ubiquitin-related modifier (SUMO) proteins are reversibly coupled to numerous intracellular targets and modulate their interactions, localization, activity or stability. Recent advances in the SUMO field have uncovered the first SUMO E3 ligases and point to a complex family of isopeptidases. SUMO has been linked to many different pathways, including nucleocytoplasmic transport. Modifying enzymes and an isopeptidase have been detected at nuclear pore complexes. In addition, studies in yeast suggest a requirement of SUMO conjugation for nuclear protein import, and specific SUMO targets depend on modification for nuclear import or export. |
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| Item Description: | Gesehen am 17.08.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1362-4326 |
| DOI: | 10.1016/j.tibs.2003.09.002 |