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Glyoxal in hyperglycaemic ischemic stroke - a cohort study

Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even in the absence of pre-existing diabetes. However, in clinical trials treatment of elevated glucose levels with insulin did not improve stroke outcome, suggesting that collateral effects rather than hyperglycaemia i...

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Main Authors: Rhein, Sina (Author) , Inderhees, Julica (Author) , Herrmann, Oliver (Author) , Othman, Alaa (Author) , Begemann, Kimberly (Author) , Fleming, Thomas (Author) , Nawroth, Peter Paul (Author) , Klika, Karel D. (Author) , Isa, Rakad (Author) , König, Inke R. (Author) , Royl, Georg (Author) , Schwaninger, Markus (Author)
Format: Article (Journal)
Language:English
Published: 2023
In: Cardiovascular diabetology
Year: 2023, Volume: 22, Pages: 1-9
ISSN:1475-2840
DOI:10.1186/s12933-023-01892-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12933-023-01892-7
Verlag, kostenfrei, Volltext: https://cardiab.biomedcentral.com/articles/10.1186/s12933-023-01892-7
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Author Notes:Sina Rhein, Julica Inderhees, Oliver Herrmann, Alaa Othman, Kimberly Begemann, Thomas Fleming, Peter P. Nawroth, Karel D. Klika, Rakad Isa, Inke R. König, Georg Royl and Markus Schwaninger
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Summary:Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even in the absence of pre-existing diabetes. However, in clinical trials treatment of elevated glucose levels with insulin did not improve stroke outcome, suggesting that collateral effects rather than hyperglycaemia itself aggravate ischemic brain damage. As reactive glucose metabolites, glyoxal and methylglyoxal are candidates for mediating the deleterious effects of hyperglycaemia in acute stroke.
Item Description:Veröffentlicht: 12. Juli 2023
Gesehen am 22.08.2023
Physical Description:Online Resource
ISSN:1475-2840
DOI:10.1186/s12933-023-01892-7

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