Early SARS-CoV-2 infection: platelet-neutrophil complexes and platelet function
Background - Conflicting results have been reported on platelet activity ex vivo and responsiveness in vitro among patients with COVID-19 with or without thromboembolic complications. - Objectives - To assess platelet reactivity in patients with moderate disease at early stages of COVID-19. - Method...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2023
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| In: |
Research and practice in thrombosis and haemostasis
Year: 2023, Volume: 7, Issue: 1, Pages: 1-12 |
| ISSN: | 2475-0379 |
| DOI: | 10.1016/j.rpth.2022.100025 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.rpth.2022.100025 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2475037922022762 
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| Author Notes: | Marina Rieder, Niklas Baldus, Daniela Stallmann, Maren Jeserich, Isabella Goller, Luisa Wirth, Luisa Pollmeier, Maike Hofmann, Christoph Bode, Hans-Joerg Busch, Bonaventura Schmid, Nadine Gauchel, Rüdiger E. Scharf, Daniel Duerschmied, Achim Lother, Krystin Krauel |
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| 520 | |a Background - Conflicting results have been reported on platelet activity ex vivo and responsiveness in vitro among patients with COVID-19 with or without thromboembolic complications. - Objectives - To assess platelet reactivity in patients with moderate disease at early stages of COVID-19. - Methods - We performed a prospective, descriptive analysis of 100 consecutive patients presenting with suspected SARS-CoV-2 infection at University Medical Center Freiburg during the first or second wave of the pandemic. Following polymerase chain reaction testing and compliance with study inclusion criteria, 20 SARS-CoV-2-positive and 55 SARS-CoV-2-negative patients (serving as patient controls) were enrolled. In addition, 15 healthy subjects were included. Platelet reactivity was assessed using whole-blood impedance aggregometry and flow cytometry in response to various agonists. - Results - Platelet aggregation was significantly impaired in the patients with COVID-19 compared with that in the patient controls or healthy subjects. The reduced platelet responsiveness in the patients with COVID-19 was associated with impaired activation of GPIIb/IIIa (αIIbβ3). In contrast, low expression of P-selectin at baseline and intact secretion upon stimulation in vitro suggest that no preactivation in vivo, leading to “exhausted” platelets, had occurred. The proportion of circulating platelet-neutrophil complexes was significantly higher in the patients with COVID-19 (mean ± SD, 41% ± 13%) than in the patient controls (18% ± 7%; 95% CI, 11.1-34.1; P = .0002) or healthy subjects (17% ± 4%; 95% CI, 13.8-33.8; P < .0001). An analysis of neutrophil adhesion receptors revealed upregulation of CD11b (α-subunit of αMβ2) and CD66b (CEACAM8) but not of CD162 (PSGL-1) in the patients with COVID-19. - Conclusion - Despite reduced platelet responsiveness, platelet-neutrophil complexes are increased at early stages of moderate disease. Thus, this cellular interaction may occur during COVID-19 without preceding platelet activation. | ||
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