Enhanced Ca2+-dependent SK-channel gating and membrane trafficking in human atrial fibrillation

Small-conductance Ca2+-activated K+ (SK)-channel inhibitors have antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel antiarrhythmic option. However, the regulation of SK-channels in human atrial cardiomyocytes and its modification in patients with AF are...

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Main Authors:	Heijman, Jordi (Author) , Zhou, Xiao-Bo (Author) , Morotti, Stefano (Author) , Molina, Cristina E. (Author) , Abu-Taha, Issam H. (Author) , Tekook, Marcel (Author) , Jespersen, Thomas (Author) , Zhang, Yiqiao (Author) , Dobrev, Shokoufeh (Author) , Milting, Hendrik (Author) , Gummert, Jan (Author) , Karck, Matthias (Author) , Kamler, Markus (Author) , El-Armouche, Ali (Author) , Saljic, Arnela (Author) , Grandi, Eleonora (Author) , Nattel, Stanley (Author) , Dobrev, Dobromir (Author)
Format:	Article (Journal)
Language:	English
Published:	April 28, 2023
In:	Circulation research Year: 2023, Volume: 132, Issue: 9, Pages: e116-e133
ISSN:	1524-4571
DOI:	10.1161/CIRCRESAHA.122.321858
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCRESAHA.122.321858 Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321858
Author Notes:	Jordi Heijman, Xiaobo Zhou, Stefano Morotti, Cristina E. Molina, Issam H. Abu-Taha, Marcel Tekook, Thomas Jespersen, Yiqiao Zhang, Shokoufeh Dobrev, Hendrik Milting, Jan Gummert, Matthias Karck, Markus Kamler, Ali El-Armouche, Arnela Saljic, Eleonora Grandi, Stanley Nattel, Dobromir Dobrev