Enhanced Ca2+-dependent SK-channel gating and membrane trafficking in human atrial fibrillation
Small-conductance Ca2+-activated K+ (SK)-channel inhibitors have antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel antiarrhythmic option. However, the regulation of SK-channels in human atrial cardiomyocytes and its modification in patients with AF are...
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Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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Dokumenttyp: | Article (Journal) |
Sprache: | Englisch |
Veröffentlicht: |
April 28, 2023
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In: |
Circulation research
Year: 2023, Jahrgang: 132, Heft: 9, Pages: e116-e133 |
ISSN: | 1524-4571 |
DOI: | 10.1161/CIRCRESAHA.122.321858 |
Online-Zugang: | lizenzpflichtig lizenzpflichtig ![]() |
Verfasserangaben: | Jordi Heijman, Xiaobo Zhou, Stefano Morotti, Cristina E. Molina, Issam H. Abu-Taha, Marcel Tekook, Thomas Jespersen, Yiqiao Zhang, Shokoufeh Dobrev, Hendrik Milting, Jan Gummert, Matthias Karck, Markus Kamler, Ali El-Armouche, Arnela Saljic, Eleonora Grandi, Stanley Nattel, Dobromir Dobrev |
Zusammenfassung: | Small-conductance Ca2+-activated K+ (SK)-channel inhibitors have antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel antiarrhythmic option. However, the regulation of SK-channels in human atrial cardiomyocytes and its modification in patients with AF are poorly understood and were the object of this study. |
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Beschreibung: | Online veröffentlicht am 17. März 2023 Im Titel erscheint der Ausdruck "2+" hochgestellt Gesehen am 20.12.2023 |
Beschreibung: | Online Resource |
ISSN: | 1524-4571 |
DOI: | 10.1161/CIRCRESAHA.122.321858 |