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Exercise elevates serum brain-derived neurotrophic factor in partially remitted depression

Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven par...

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Main Authors: Kramer, Benedikt Alexander (Author) , Jähn, Anna (Author) , Grützner, Thea M. (Author) , Hess, Natalie Sarah (Author) , Bellanti, Amanda (Author) , Listunova, Lena (Author) , Hellweg, Rainer (Author) , Weisbrod, Matthias (Author) , Roesch-Ely, Daniela (Author)
Format: Article (Journal)
Language:English
Published: 3 June 2023
In: Psychiatry research
Year: 2023, Volume: 326, Pages: 1-3
ISSN:1872-7123
DOI:10.1016/j.psychres.2023.115283
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.psychres.2023.115283
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165178123002330
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Author Notes:Benedikt Alexander Kramer, Anna Jaehn, Thea Marianne Grützner, Natalie Sarah Hess, Amanda Bellanti, Lena Listunova, Rainer Hellweg, Matthias Weisbrod, Daniela Roesch Ely
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Summary:Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven participants with partially remitted MDD were allocated to either a bout of strenuous or light activity. Serum was collected before and after the intervention. BDNF was measured using a highly sensitive and specific enzyme-linked immunosorbent assay. Significant BDNF elevation in the strenuous activity group emerged. This study confirms exercise-dependent serum BDNF elevation in MDD. Preregistration: German Clinical Trials Register (DRKS0001515).
Item Description:Gesehen am 23.08.2023
Online verfügbar: 3 June 2023, Dokumentversion: 7 June 2023
Physical Description:Online Resource
ISSN:1872-7123
DOI:10.1016/j.psychres.2023.115283

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