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Cachexia: a systemic consequence of progressive, unresolved disease

Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic...

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Main Authors: Ferrer, Miriam Coronel (Author) , Anthony, Tracy G. (Author) , Ayres, Janelle S. (Author) , Biffi, Giulia (Author) , Brown, Justin C. (Author) , Caan, Bette J. (Author) , Cespedes Feliciano, Elizabeth M. (Author) , Coll, Anthony P. (Author) , Dunne, Richard F. (Author) , Goncalves, Marcus D. (Author) , Grethlein, Jonas (Author) , Heymsfield, Steven B. (Author) , Hui, Sheng (Author) , Jamal-Hanjani, Mariam (Author) , Lam, Jie Min (Author) , Lewis, David Y. (Author) , McCandlish, David (Author) , Mustian, Karen M. (Author) , O’Rahilly, Stephen (Author) , Perrimon, Norbert (Author) , White, Eileen P. (Author) , Janowitz, Tobias (Author)
Format: Article (Journal)
Language:English
Published: 27 April 2023
In: Cell
Year: 2023, Volume: 186, Issue: 9, Pages: 1824-1845
ISSN:1097-4172
DOI:10.1016/j.cell.2023.03.028
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2023.03.028
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0092867423003252
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Author Notes:Miriam Ferrer, Tracy G. Anthony, Janelle S. Ayres, Giulia Biffi, Justin C. Brown, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Anthony P. Coll, Richard F. Dunne, Marcus D. Goncalves, Jonas Grethlein, Steven B. Heymsfield, Sheng Hui, Mariam Jamal-Hanjani, Jie Min Lam, David Y. Lewis, David McCandlish, Karen M. Mustian, Stephen O’Rahilly, Norbert Perrimon, Eileen P. White, and Tobias Janowitz
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Summary:Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away from advanced cachexia to the etiology of cachexia may enable discoveries of new therapeutic approaches. Here, we review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. Evidence is emerging that distinct inflammatory, metabolic, and neuro-modulatory drivers can initiate processes that ultimately converge on advanced cachexia.
Item Description:Gesehen am 29.11.2023
Physical Description:Online Resource
ISSN:1097-4172
DOI:10.1016/j.cell.2023.03.028

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