Free-flap reconstruction in early-stage squamous cell carcinoma of the oral cavity - a prospective monocentric trial to evaluate oncological outcome and quality of life
Surgery is generally accepted as standard treatment in oral cancer, but the reconstructive procedures remain a matter of debate. The aim of this study was to evaluate oncological outcome and quality of life following surgical resection and free-flap reconstruction in patients with early oral squamou...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2023
|
| In: |
Journal of Clinical Medicine
Year: 2023, Volume: 12, Issue: 14, Pages: 1-12 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm12144833 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm12144833 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/12/14/4833 
|
| Author Notes: | Julius Moratin, Sven Zittel, Dominik Horn, Rouven Behnisch, Oliver Ristow, Michael Engel, Jürgen Hoffmann, Kolja Freier and Christian Freudlsperger |
| Summary: | Surgery is generally accepted as standard treatment in oral cancer, but the reconstructive procedures remain a matter of debate. The aim of this study was to evaluate oncological outcome and quality of life following surgical resection and free-flap reconstruction in patients with early oral squamous cell carcinoma. The presented trial was performed as a prospective, single-center observation study. Inclusion criteria were primary surgery in early-stage oral squamous cell carcinoma with free-flap reconstruction. Endpoints were overall and progression-free survival and quality of life up to 24 months after surgery. Twenty-six patients were included. Overall survival was 100% and progression-free survival was 92.3% in a maximum follow-up time of 21 months. Global quality of life showed no significant alteration after surgery. Patients reported a significant reduction in pain (p = 0.048) and a decreasing impairment of speech one year after surgery (p = 0.021). Free-flap reconstruction is a safe procedure that results in excellent oncological outcome and quality of life. Functional outcome is of high relevance in early-stage tumors of the head and neck and may mostly be affected by reconstructive procedures. Therefore, a prospective evaluation to explore success and the effects of surgical therapy is highly warranted. |
|---|---|
| Item Description: | Veröffentlicht: 22. Juli 2023 Gesehen am 24.08.2023 |
| Physical Description: | Online Resource |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm12144833 |