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Decreased level of serum NT-proCNP associates with disease severity in COVID-19

C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, cor...

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Main Authors: Bojti, Istvan (Author) , Przewosnik, Anne-Sophie (Author) , Luxenburger, Hendrik (Author) , Hofmann, Maike (Author) , Neumann-Haefelin, Christoph (Author) , Eßer, Jennifer (Author) , Siegel, Patrick Malcolm (Author) , Maier, Alexander Andreas (Author) , Bojtiné Kovács, Sarolta (Author) , Kardos, Laszlo (Author) , Csanádi, Zoltan (Author) , Rieder, Marina (Author) , Dürschmied, Daniel (Author) , Lother, Achim (Author) , Bode, Christoph (Author) , Szabó, Gabor Tamas (Author) , Czuriga, Dániel (Author)
Format: Article (Journal)
Language:English
Published: 29 June 2023
In: Respiratory research
Year: 2023, Volume: 24, Pages: 1-12
ISSN:1465-993X
DOI:10.1186/s12931-023-02469-4
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12931-023-02469-4
Verlag, kostenfrei, Volltext: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-023-02469-4
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Author Notes:Istvan Bojti, Anne-Sophie Przewosnik, Hendrik Luxenburger, Maike Hofmann, Christoph Neumann-Haefelin, Jennifer S. Esser, Patrick M. Siegel, Alexander Maier, Sarolta Bojtine Kovacs, Laszlo Kardos, Zoltan Csanádi, Marina Rieder, Daniel Duerschmied, Achim Lother, Christoph Bode, Gabor Tamas Szabó and Daniel Czuriga
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Summary:C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, correlates with disease severity and indicates a poor outcome. It is not yet known whether NT-proCNP also correlates with the clinical outcome of patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the current study, we aimed to determine possible changes in the NT-proCNP levels of patients with coronavirus disease 2019 (COVID-19), with special regard to disease severity and outcome.
Item Description:Gesehen am 25.08.2023
Physical Description:Online Resource
ISSN:1465-993X
DOI:10.1186/s12931-023-02469-4

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