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Decreased level of serum NT-proCNP associates with disease severity in COVID-19

C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, cor...

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Hauptverfasser: Bojti, Istvan (VerfasserIn) , Przewosnik, Anne-Sophie (VerfasserIn) , Luxenburger, Hendrik (VerfasserIn) , Hofmann, Maike (VerfasserIn) , Neumann-Haefelin, Christoph (VerfasserIn) , Eßer, Jennifer (VerfasserIn) , Siegel, Patrick Malcolm (VerfasserIn) , Maier, Alexander Andreas (VerfasserIn) , Bojtiné Kovács, Sarolta (VerfasserIn) , Kardos, Laszlo (VerfasserIn) , Csanádi, Zoltan (VerfasserIn) , Rieder, Marina (VerfasserIn) , Dürschmied, Daniel (VerfasserIn) , Lother, Achim (VerfasserIn) , Bode, Christoph (VerfasserIn) , Szabó, Gabor Tamas (VerfasserIn) , Czuriga, Dániel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 June 2023
In: Respiratory research
Year: 2023, Jahrgang: 24, Pages: 1-12
ISSN:1465-993X
DOI:10.1186/s12931-023-02469-4
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12931-023-02469-4
Verlag, kostenfrei, Volltext: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-023-02469-4
Volltext
Verfasserangaben:Istvan Bojti, Anne-Sophie Przewosnik, Hendrik Luxenburger, Maike Hofmann, Christoph Neumann-Haefelin, Jennifer S. Esser, Patrick M. Siegel, Alexander Maier, Sarolta Bojtine Kovacs, Laszlo Kardos, Zoltan Csanádi, Marina Rieder, Daniel Duerschmied, Achim Lother, Christoph Bode, Gabor Tamas Szabó and Daniel Czuriga
Beschreibung
Zusammenfassung:C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, correlates with disease severity and indicates a poor outcome. It is not yet known whether NT-proCNP also correlates with the clinical outcome of patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the current study, we aimed to determine possible changes in the NT-proCNP levels of patients with coronavirus disease 2019 (COVID-19), with special regard to disease severity and outcome.
Beschreibung:Gesehen am 25.08.2023
Beschreibung:Online Resource
ISSN:1465-993X
DOI:10.1186/s12931-023-02469-4

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