Dynamic contrast-enhanced MR imaging evaluation of perfusional changes and ablation zone size after combination embolization and ablation therapy
Purpose - The objectives of this study were to assess the utility of dynamic contrast-enhanced magnetic resonance (MR) imaging in quantifying parenchymal perfusional changes after embolization and to characterize the association between pharmacokinetic (PK) parameters and final microwave ablation vo...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2023
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| In: |
Journal of vascular and interventional radiology
Year: 2023, Volume: 34, Issue: 2, Pages: 253-260 |
| ISSN: | 1535-7732 |
| DOI: | 10.1016/j.jvir.2022.10.041 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jvir.2022.10.041 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1051044322013203 
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| Author Notes: | Jason Chiang, Hiro Sparks, Johann S. Rink, M. Franca Meloni, Frank Hao, Kyung H. Sung, and Edward W. Lee |
| Summary: | Purpose - The objectives of this study were to assess the utility of dynamic contrast-enhanced magnetic resonance (MR) imaging in quantifying parenchymal perfusional changes after embolization and to characterize the association between pharmacokinetic (PK) parameters and final microwave ablation volume. - Materials and Methods - PK parameters from dynamic contrast-enhanced MR imaging were used to quantify perfusional changes in the liver after transarterial embolization of the right or left lobe in a swine liver model (n = 5). Each animal subject subsequently underwent microwave ablation (60 W for 5 minutes) of the embolized and nonembolized liver lobes. Changes in PK parameters from dynamic contrast-enhanced MR imaging were correlated with their respective final microwave ablation volumes in each liver lobe. - Results - Microwave ablation volumes of embolized liver lobes were significantly larger than those of nonembolized liver lobes (28.0 mL ± 6.2 vs 15.1 mL ± 5.2, P < .001). PK perfusion parameters were significantly lower in embolized liver lobes than in nonembolized liver lobes (Ktrans = 0.69 min−1 ± 0.15 vs 1.52 min−1 ± 0.37, P < .001; kep = 0.69 min−1 ± 0.19 vs 1.54 min−1 ± 0.42, P < .001). There was a moderate but significant correlation between normalized kep and ablation volume, with each unit increase in normalized kep corresponding to a 9.8-mL decrease in ablation volume (P = .035). - Conclusions - PK-derived parameters from dynamic contrast-enhanced MR imaging can be used to quantify perfusional changes after transarterial embolization and are directly inversely correlated with final ablation volume. |
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| Item Description: | Online verfügbar: 8. November 2022, Artikelversion: 24. Januar 2023 Gesehen am 28.08.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1535-7732 |
| DOI: | 10.1016/j.jvir.2022.10.041 |