On the proportion of cancer stem cells in a tumour
It is now generally accepted that cancers contain a sub-population, the cancer stem cells (CSCs), which initiate and drive a tumour’s growth. At least until recently it has been widely assumed that only a small proportion of the cells in a tumour are CSCs. Here we use a mathematical model, supported...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[21 October 2010]
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| In: |
Journal of theoretical biology
Year: 2010, Volume: 266, Issue: 4, Pages: 708-711 |
| ISSN: | 1095-8541 |
| DOI: | 10.1016/j.jtbi.2010.07.031 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jtbi.2010.07.031 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022519310003887 
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| Author Notes: | Matthew D. Johnston, Philip K. Maini, S. Jonathan Chapman, Carina M. Edwards, Walter F. Bodmer |
| Summary: | It is now generally accepted that cancers contain a sub-population, the cancer stem cells (CSCs), which initiate and drive a tumour’s growth. At least until recently it has been widely assumed that only a small proportion of the cells in a tumour are CSCs. Here we use a mathematical model, supported by experimental evidence, to show that such an assumption is unwarranted. We show that CSCs may comprise any possible proportion of the tumour, and that the higher the proportion the more aggressive the tumour is likely to be. |
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| Item Description: | Gesehen am 28.08.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1095-8541 |
| DOI: | 10.1016/j.jtbi.2010.07.031 |