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Role of diabetes in collateral status assessed in CT perfusion-derived dynamic CTA in anterior circulation stroke

Purpose  Diabetes is associated with vascular dysfunction potentially impairing collateral recruitment in acute ischemic stroke. This retrospective study aimed at analyzing the impact of diabetes on collateralization assessed on dynamic CTA. - Methods  Collaterals were retrospectively assessed on CT...

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Main Authors: Scheidecker, Emilia (Author) , Pereira-Zimmermann, Benjamin (Author) , Potreck, Arne (Author) , Vollherbst, Dominik (Author) , Möhlenbruch, Markus Alfred (Author) , Gumbinger, Christoph (Author) , Bendszus, Martin (Author) , Herweh, Christian (Author) , Seker, Fatih (Author)
Format: Article (Journal)
Language:English
Published: 2022
In: Neuroradiology
Year: 2022, Volume: 64, Issue: 6, Pages: 1195-1199
ISSN:1432-1920
DOI:10.1007/s00234-021-02873-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00234-021-02873-x
Verlag, kostenfrei, Volltext: https://link.springer.com/10.1007/s00234-021-02873-x
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Author Notes:Emilia Scheidecker, Benjamin Pereira-Zimmermann, Arne Potreck, Dominik F. Vollherbst, Markus A. Möhlenbruch, Christoph Gumbinger, Martin Bendszus, Christian Herweh, Fatih Seker
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Summary:Purpose  Diabetes is associated with vascular dysfunction potentially impairing collateral recruitment in acute ischemic stroke. This retrospective study aimed at analyzing the impact of diabetes on collateralization assessed on dynamic CTA. - Methods  Collaterals were retrospectively assessed on CT perfusion-derived dynamic CTA according to the mCTA score by Menon in a cohort of patients with an acute occlusion of the M1 segment or carotid T. The extent of collateral circulation was related to the history of diabetes and to admission blood glucose and HbA1c levels. - Results  Two hundred thirty-nine patients were included. The mCTA collateral score was similar in patients with diabetes (median 3, interquartile range 3-4) and without diabetes (median 4, interquartile range 3-4) (P = 0.823). Diabetes was similarly frequent in patients with good (18.8%), intermediate (16.1%), and poor collaterals (16.0%) (P = 0.355). HbA1c was non-significantly higher in patients with poor collaterals (6.3 ± 1.5) compared to patients with intermediate (6.0 ± 0.9) and good collaterals (5.8 ± 0.9) (P = 0.061). Blood glucose levels were significantly higher in patients with poor compared to good collaterals (mean 141.6 vs. 121.8 mg/dl, P = 0.045). However, there was no significant difference between good and intermediate collaterals (mean 121.8 vs. 129.5 mg/dl, P = 0.161) as well as between intermediate and poor collaterals (129.5 vs. 141.6 mg/dl, P = 0.161). - Conclusion  There was no statistically significant difference among patients with good, intermediate, and poor collaterals regarding the presence of diabetes or HbA1c level on admission. However, stroke patients with poor collaterals tend to have higher blood glucose and HbA1c levels.
Item Description:Online Veröffentlicht: 9 Dezember 2021
Gesehen am 28.08.2023
Physical Description:Online Resource
ISSN:1432-1920
DOI:10.1007/s00234-021-02873-x

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