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Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants

Cognitive impairment is a common feature in schizophrenia and the strongest prognostic factor for long-term outcome. Identifying a trait associated with the genetic background for cognitive outcome in schizophrenia may aid in a deeper understanding of clinical disease subtypes. Fast sleep spindles m...

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Main Authors: Schilling, Claudia (Author) , Zillich, Lea (Author) , Schredl, Michael (Author) , Frank, Josef (Author) , Schwarz, Emanuel (Author) , Deuschle, Michael (Author) , Meyer-Lindenberg, Andreas (Author) , Rietschel, Marcella (Author) , Witt, Stephanie (Author) , Streit, Fabian (Author)
Format: Article (Journal)
Language:English
Published: 20 June 2022
In: European archives of psychiatry and clinical neuroscience
Year: 2022, Volume: 272, Issue: 7, Pages: 1193-1203
ISSN:1433-8491
DOI:10.1007/s00406-022-01435-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00406-022-01435-3
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00406-022-01435-3
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Author Notes:Claudia Schilling, Lea Zillich, Michael Schredl, Josef Frank, Emanuel Schwarz, Michael Deuschle, Andreas Meyer-Lindenberg, Marcella Rietschel, Stephanie H. Witt, Fabian Streit
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Summary:Cognitive impairment is a common feature in schizophrenia and the strongest prognostic factor for long-term outcome. Identifying a trait associated with the genetic background for cognitive outcome in schizophrenia may aid in a deeper understanding of clinical disease subtypes. Fast sleep spindles may represent such a biomarker as they are strongly genetically determined, associated with cognitive functioning and impaired in schizophrenia and unaffected relatives. We measured fast sleep spindle density in 150 healthy adults and investigated its association with a genome-wide polygenic score for schizophrenia (SCZ-PGS). The association between SCZ-PGS and fast spindle density was further characterized by stratifying it to the genetic background of intelligence. SCZ-PGS was positively associated with fast spindle density. This association mainly depended on pro-cognitive genetic variants. Our results strengthen the evidence for a genetic background of spindle abnormalities in schizophrenia. Spindle density might represent an easily accessible marker for a favourable cognitive outcome which should be further investigated in clinical samples.
Item Description:Gesehen am 04.09.2023
Physical Description:Online Resource
ISSN:1433-8491
DOI:10.1007/s00406-022-01435-3

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