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High temporal resolution dual-source photon-counting CT for coronary artery disease: initial multicenter clinical experience

The aim of this paper is to evaluate the diagnostic image quality of spectral dual-source photon-counting detector coronary computed tomography angiography (PCD-CCTA) for coronary artery disease in a multicenter study. The image quality (IQ), assessability, contrast-to-noise ratio (CNR), Agatston sc...

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Main Authors: Soschynski, Martin (Author) , Hagen, Florian (Author) , Baumann, Stefan (Author) , Hagar, Muhammad Taha (Author) , Weiss, Jakob (Author) , Krauß, Tobias (Author) , Schlett, Christopher L. (Author) , Zur Mühlen, Constantin von (Author) , Bamberg, Fabian (Author) , Nikolaou, Konstantin (Author) , Greulich, Simon (Author) , Froelich, Matthias F. (Author) , Riffel, Philipp (Author) , Overhoff, Daniel (Author) , Papavassiliu, Theano (Author) , Schönberg, Stefan (Author) , Faby, Sebastian (Author) , Ulzheimer, Stefan (Author) , Ayx, Isabelle (Author) , Krumm, Patrick (Author)
Format: Article (Journal)
Language:English
Published: 11 October 2022
In: Journal of Clinical Medicine
Year: 2022, Volume: 11, Issue: 20, Pages: 1-15
ISSN:2077-0383
DOI:10.3390/jcm11206003
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm11206003
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/11/20/6003
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Author Notes:Martin Soschynski, Florian Hagen, Stefan Baumann, Muhammad Taha Hagar, Jakob Weiss, Tobias Krauss, Christopher L. Schlett, Constantin von zur Mühlen, Fabian Bamberg, Konstantin Nikolaou, Simon Greulich, Matthias F. Froelich, Philipp Riffel, Daniel Overhoff, Theano Papavassiliu, Stefan O. Schoenberg, Sebastian Faby, Stefan Ulzheimer, Isabelle Ayx and Patrick Krumm
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Summary:The aim of this paper is to evaluate the diagnostic image quality of spectral dual-source photon-counting detector coronary computed tomography angiography (PCD-CCTA) for coronary artery disease in a multicenter study. The image quality (IQ), assessability, contrast-to-noise ratio (CNR), Agatston score, and radiation exposure were measured. Stenoses were quantified and compared with invasive coronary angiography, if available. A total of 92 subjects (65% male, age 58 ± 14 years) were analyzed. The prevalence of significant coronary artery disease (CAD) (stenosis ≥ 50%) was 17% of all patients, the range of the Agatston score was 0-2965 (interquartile range (IQR) 0-135). The IQ was very good (one, IQR one-two), the CNR was very high (20 ± 10), and 5% of the segments were rated non-diagnostic. The IQ and assessability were higher in proximal coronary segments (p < 0.001). Agatston scores up to 600 did not significantly affect the assessability of the coronary segments (p = 0.3). Heart rate influenced assessability only at a high-pitch mode (p = 0.009). For the invasive coronary angiography (ICA) subgroup (n = nine), the diagnostic performance for CAD per segment was high (sensitivity 92%, specificity 96%), although the limited number of patients who underwent both diagnostic modalities limits the generalization of this finding at this stage. PCD-CCTA provides good image quality for low and moderate levels of coronary calcifications.
Item Description:Gesehen am 05.09.2023
Physical Description:Online Resource
ISSN:2077-0383
DOI:10.3390/jcm11206003

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