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Improved T and B cell recovery by the transfer of slowly dividing human hematopoietic stem cells

Human hematopoietic stem cells giving rise to long term initiating cells in vitro are enriched in a CD34+ slow dividing fraction (SDF). Here, we tested reconstitution and multilineage differentiation of this CD34+ SDF in NOD/SCID mice. In the bone marrow a slightly higher percentage of human hematop...

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Bibliographic Details
Main Authors: Vitacolonna, Mario (Author) , Schubert, Mario (Author) , Herbert, Nicolás (Author) , Taubert, Isabel (Author) , Singh, Rahul (Author) , Ho, Anthony Dick (Author) , Zöller, Margot (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Leukemia research
Year: 2010, Volume: 34, Issue: 5, Pages: 622-630
ISSN:1873-5835
DOI:10.1016/j.leukres.2009.10.015
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.leukres.2009.10.015
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0145212609005086
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Author Notes:Mario Vitacolonna, Mario Schubert, Nicolás Herbert, Isabel Taubert, Rahul Singh, Anthony Ho, Margot Zöller
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Summary:Human hematopoietic stem cells giving rise to long term initiating cells in vitro are enriched in a CD34+ slow dividing fraction (SDF). Here, we tested reconstitution and multilineage differentiation of this CD34+ SDF in NOD/SCID mice. In the bone marrow a slightly higher percentage of human hematopoietic progenitors were recovered after the transfer of the SDF compared to the fast dividing fraction. Instead, T cell maturation in the rudimentary thymus and lymph node repopulation was only initiated by the SDF. The capacity of the SDF to differentiate and mature in the patients’ thymus could provide an advantage in immunocompetence recovery.
Item Description:Online veröffentlicht am 10. November 2009
Gesehen am 07.09.2023
Physical Description:Online Resource
ISSN:1873-5835
DOI:10.1016/j.leukres.2009.10.015

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