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Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes

Cardiac hypertrophy is an independent risk for heart failure (HF) and sudden death. Deciphering signalling pathways dependent on extracellular calcium (Ca2+) influx that control normal and pathological cardiac growth may enable identification of novel therapeutic targets. The objective of the presen...

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Main Authors: Völkers, Mirko (Author) , Zielonka, Mareen (Author) , Herzog, Nicole (Author) , Frank, Derk (Author) , Dolatabadi, Nima (Author) , Frey, Norbert (Author) , Gude, Natalie (Author) , Friedrich, Oliver (Author) , Koch, Walter J. (Author) , Katus, Hugo (Author) , Sussman, Mark A. (Author) , Most, Patrick (Author)
Format: Article (Journal)
Language:English
Published: 6 February 2010
In: Journal of molecular and cellular cardiology
Year: 2010, Volume: 48, Issue: 6, Pages: 1329-1334
ISSN:1095-8584
DOI:10.1016/j.yjmcc.2010.01.020
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.yjmcc.2010.01.020
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022282810000337
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Author Notes:Mirko Voelkers, Mareen Salz, Nicole Herzog, Derk Frank, Nima Dolatabadi, Norbert Frey, Natalie Gude, Oliver Friedrich, Walter J. Koch, Hugo A. Katus, Mark A. Sussman, Patrick Most
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Summary:Cardiac hypertrophy is an independent risk for heart failure (HF) and sudden death. Deciphering signalling pathways dependent on extracellular calcium (Ca2+) influx that control normal and pathological cardiac growth may enable identification of novel therapeutic targets. The objective of the present study is to determine the role of the Ca2+ release-activated Ca2+ (CRAC) channel Orai1 and stromal interaction molecule 1 (Stim1) in postnatal cardiomyocyte store operated Ca2+ entry (SOCE) and impact on normal and hypertrophic postnatal cardiomyocyte growth.
Item Description:Gesehen am 07.09.2023
Physical Description:Online Resource
ISSN:1095-8584
DOI:10.1016/j.yjmcc.2010.01.020

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