Interaction of heparin with cationic molecular probes: probe charge is a major determinant of binding stoichiometry and affinity
Fluorescent perylenediimide probes modified with 2, 4, 6, or 8 ammonium groups were synthesized and their binding to the antithrombotic drug heparin was studied by fluorescence spectroscopy in solution. The polyanionic polysaccharide strands of heparin bind more probe molecules per sugar unit when t...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 January 2010
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| In: |
Bioorganic & medicinal chemistry letters
Year: 2010, Volume: 20, Issue: 4, Pages: 1445-1447 |
| ISSN: | 1464-3405 |
| DOI: | 10.1016/j.bmcl.2009.12.105 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bmcl.2009.12.105 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0960894X09018289 
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| Author Notes: | Helga Szelke, Sarah Schübel, Job Harenberg, Roland Krämer |
| Summary: | Fluorescent perylenediimide probes modified with 2, 4, 6, or 8 ammonium groups were synthesized and their binding to the antithrombotic drug heparin was studied by fluorescence spectroscopy in solution. The polyanionic polysaccharide strands of heparin bind more probe molecules per sugar unit when the charge of the latter is low, and stability of the probe-heparin complex increases with increasing probe charge. |
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| Item Description: | Gesehen am 08.09.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1464-3405 |
| DOI: | 10.1016/j.bmcl.2009.12.105 |