Interaction of heparin with cationic molecular probes: probe charge is a major determinant of binding stoichiometry and affinity
Fluorescent perylenediimide probes modified with 2, 4, 6, or 8 ammonium groups were synthesized and their binding to the antithrombotic drug heparin was studied by fluorescence spectroscopy in solution. The polyanionic polysaccharide strands of heparin bind more probe molecules per sugar unit when t...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 January 2010
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| In: |
Bioorganic & medicinal chemistry letters
Year: 2010, Jahrgang: 20, Heft: 4, Pages: 1445-1447 |
| ISSN: | 1464-3405 |
| DOI: | 10.1016/j.bmcl.2009.12.105 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bmcl.2009.12.105 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0960894X09018289 
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| Verfasserangaben: | Helga Szelke, Sarah Schübel, Job Harenberg, Roland Krämer |
| Zusammenfassung: | Fluorescent perylenediimide probes modified with 2, 4, 6, or 8 ammonium groups were synthesized and their binding to the antithrombotic drug heparin was studied by fluorescence spectroscopy in solution. The polyanionic polysaccharide strands of heparin bind more probe molecules per sugar unit when the charge of the latter is low, and stability of the probe-heparin complex increases with increasing probe charge. |
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| Beschreibung: | Gesehen am 08.09.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1464-3405 |
| DOI: | 10.1016/j.bmcl.2009.12.105 |