Mitochondrien unter Stress: die Rolle der Präsequenzprotease MPP
Abstract - The majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational preprotein import from the cytosol. Proteomic imbalances are sensed and induce cellular stress response pathways to restore proteostasis. Here, t...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | German |
| Published: |
26 June 2021
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| In: |
Biospektrum
Year: 2021, Volume: 27, Issue: 4, Pages: 390-393 |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-021-1589-1 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s12268-021-1589-1 Verlag, kostenfrei, Volltext: https://link.springer.com/10.1007/s12268-021-1589-1 
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| Author Notes: | F.-Nora Vögtle |
| Summary: | Abstract - The majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational preprotein import from the cytosol. Proteomic imbalances are sensed and induce cellular stress response pathways to restore proteostasis. Here, the mitochondrial presequence protease MPP serves as example to illustrate the critical role of mitochondrial protein biogenesis and proteostasis on cellular integrity. |
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| Item Description: | Gesehen am 11.09.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-021-1589-1 |