Mitochondrien unter Stress: die Rolle der Präsequenzprotease MPP
Abstract - The majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational preprotein import from the cytosol. Proteomic imbalances are sensed and induce cellular stress response pathways to restore proteostasis. Here, t...
Gespeichert in:
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Deutsch |
| Veröffentlicht: |
26 June 2021
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Biospektrum
Year: 2021, Jahrgang: 27, Heft: 4, Pages: 390-393 |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-021-1589-1 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s12268-021-1589-1 Verlag, kostenfrei, Volltext: https://link.springer.com/10.1007/s12268-021-1589-1 
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| Verfasserangaben: | F.-Nora Vögtle |
| Zusammenfassung: | Abstract - The majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational preprotein import from the cytosol. Proteomic imbalances are sensed and induce cellular stress response pathways to restore proteostasis. Here, the mitochondrial presequence protease MPP serves as example to illustrate the critical role of mitochondrial protein biogenesis and proteostasis on cellular integrity. |
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| Beschreibung: | Gesehen am 11.09.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-021-1589-1 |