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CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus

CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1- and A2-mediated steady-state currents, but did not affect kainate- or N-methyl- d-aspartate (...

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Main Authors: Engelhardt, Jakob von (Author) , Mack, Volker (Author) , Sprengel, Rolf (Author) , Kavenstock, Netta (Author) , Li, Ka Wan (Author) , Stern-Bach, Yael (Author) , Smit, August B. (Author) , Seeburg, Peter H. (Author) , Monyer, Hannah (Author)
Format: Article (Journal)
Language:English
Published: 25 Feb 2010
In: Science
Year: 2010, Volume: 327, Issue: 5972, Pages: 1518-1522
ISSN:1095-9203
DOI:10.1126/science.1184178
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.1184178
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.1184178
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Author Notes:Jakob von Engelhardt, Volker Mack, Rolf Sprengel, Netta Kavenstock, Ka Wan Li, Yael Stern-Bach, August B. Smit, Peter H. Seeburg, Hannah Monyer
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Summary:CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1- and A2-mediated steady-state currents, but did not affect kainate- or N-methyl- d-aspartate (NMDA) receptor-mediated currents. Mouse hippocampal CA1 pyramidal neurons expressed CKAMP44 at low abundance, and overexpression of CKAMP44 led to stronger and faster AMPA receptor desensitization, slower recovery from desensitization, and a reduction in the paired-pulse ratio of AMPA currents. By contrast, dentate gyrus granule cells exhibited strong CKAMP44 expression, and CKAMP44 knockout increased the paired-pulse ratio of AMPA currents in lateral and medial perforant path-granule cell synapses. CKAMP44 thus modulates short-term plasticity at specific excitatory synapses.
Item Description:Gesehen am 13.09.2023
Physical Description:Online Resource
ISSN:1095-9203
DOI:10.1126/science.1184178

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