CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus
CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1- and A2-mediated steady-state currents, but did not affect kainate- or N-methyl- d-aspartate (...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 Feb 2010
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| In: |
Science
Year: 2010, Jahrgang: 327, Heft: 5972, Pages: 1518-1522 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.1184178 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.1184178 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.1184178 
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| Verfasserangaben: | Jakob von Engelhardt, Volker Mack, Rolf Sprengel, Netta Kavenstock, Ka Wan Li, Yael Stern-Bach, August B. Smit, Peter H. Seeburg, Hannah Monyer |
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| 520 | |a CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1- and A2-mediated steady-state currents, but did not affect kainate- or N-methyl- d-aspartate (NMDA) receptor-mediated currents. Mouse hippocampal CA1 pyramidal neurons expressed CKAMP44 at low abundance, and overexpression of CKAMP44 led to stronger and faster AMPA receptor desensitization, slower recovery from desensitization, and a reduction in the paired-pulse ratio of AMPA currents. By contrast, dentate gyrus granule cells exhibited strong CKAMP44 expression, and CKAMP44 knockout increased the paired-pulse ratio of AMPA currents in lateral and medial perforant path-granule cell synapses. CKAMP44 thus modulates short-term plasticity at specific excitatory synapses. | ||
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