The disruption of NMDAR/TRPM4 death signaling with TwinF interface inhibitors: a new pharmacological principle for neuroprotection
With the discovery that the acquisition of toxic features by extrasynaptic NMDA receptors (NMDARs) involves their physical interaction with the non-selective cation channel, TRPM4, it has become possible to develop a new pharmacological principle for neuroprotection, namely the disruption of the NMD...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 July 2023
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| In: |
Pharmaceuticals
Year: 2023, Volume: 16, Issue: 8, Pages: 1-15 |
| ISSN: | 1424-8247 |
| DOI: | 10.3390/ph16081085 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ph16081085 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1424-8247/16/8/1085 
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| Author Notes: | Jing Yan and Hilmar Bading |
| Summary: | With the discovery that the acquisition of toxic features by extrasynaptic NMDA receptors (NMDARs) involves their physical interaction with the non-selective cation channel, TRPM4, it has become possible to develop a new pharmacological principle for neuroprotection, namely the disruption of the NMDAR/TRPM4 death signaling complex. ... |
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| Item Description: | Gesehen am 14.12.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1424-8247 |
| DOI: | 10.3390/ph16081085 |