S-Adenosylhomocysteine is a useful metabolic factor in the early prediction of septic disease progression and death in critically Ill patients: a prospective cohort study
A common final pathway of pathogenetic mechanisms in septic organ dysfunction and death is a lack or non-utilization of oxygen. Plasma concentrations of lactate serve as surrogates for the oxygen-deficiency-induced imbalance between energy supply and demand. As S-adenosylhomocysteine (SAH) was shown...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
9 August 2023
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| In: |
International journal of molecular sciences
Year: 2023, Volume: 24, Issue: 16, Pages: 1-18 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms241612600 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms241612600 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/24/16/12600 
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| Author Notes: | Franz-Simon Centner, Jochen J. Schoettler, Kathrin Brohm, Sonani Mindt, Evelyn Jäger, Bianka Hahn, Tanja Fuderer, Holger A. Lindner, Verena Schneider-Lindner, Joerg Krebs, Michael Neumaier and Manfred Thiel |
| Summary: | A common final pathway of pathogenetic mechanisms in septic organ dysfunction and death is a lack or non-utilization of oxygen. Plasma concentrations of lactate serve as surrogates for the oxygen-deficiency-induced imbalance between energy supply and demand. As S-adenosylhomocysteine (SAH) was shown to reflect tissue hypoxia, we compared the ability of SAH versus lactate to predict the progression of inflammatory and septic disease to septic organ dysfunction and death. ... |
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| Item Description: | Gesehen am 20.12.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms241612600 |