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S-Adenosylhomocysteine is a useful metabolic factor in the early prediction of septic disease progression and death in critically Ill patients: a prospective cohort study

A common final pathway of pathogenetic mechanisms in septic organ dysfunction and death is a lack or non-utilization of oxygen. Plasma concentrations of lactate serve as surrogates for the oxygen-deficiency-induced imbalance between energy supply and demand. As S-adenosylhomocysteine (SAH) was shown...

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Hauptverfasser: Centner, Franz-Simon (VerfasserIn) , Schöttler, Jochen (VerfasserIn) , Brohm, Kathrin (VerfasserIn) , Mindt, Sonani (VerfasserIn) , Jäger, Evelyn (VerfasserIn) , Hahn, Bianka (VerfasserIn) , Fuderer, Tanja (VerfasserIn) , Lindner, Holger A. (VerfasserIn) , Schneider-Lindner, Verena (VerfasserIn) , Krebs, Jörg (VerfasserIn) , Neumaier, Michael (VerfasserIn) , Thiel, Manfred (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 9 August 2023
In: International journal of molecular sciences
Year: 2023, Jahrgang: 24, Heft: 16, Pages: 1-18
ISSN:1422-0067
DOI:10.3390/ijms241612600
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms241612600
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/24/16/12600
Volltext
Verfasserangaben:Franz-Simon Centner, Jochen J. Schoettler, Kathrin Brohm, Sonani Mindt, Evelyn Jäger, Bianka Hahn, Tanja Fuderer, Holger A. Lindner, Verena Schneider-Lindner, Joerg Krebs, Michael Neumaier and Manfred Thiel
Beschreibung
Zusammenfassung:A common final pathway of pathogenetic mechanisms in septic organ dysfunction and death is a lack or non-utilization of oxygen. Plasma concentrations of lactate serve as surrogates for the oxygen-deficiency-induced imbalance between energy supply and demand. As S-adenosylhomocysteine (SAH) was shown to reflect tissue hypoxia, we compared the ability of SAH versus lactate to predict the progression of inflammatory and septic disease to septic organ dysfunction and death. ...
Beschreibung:Gesehen am 20.12.2023
Beschreibung:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms241612600

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