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Synthesis of anilides by aminolysis of unactivated esters using MnCl2 in combination with strong bases as catalyst

Anilides are often found in pharmaceuticals and active ingredients in crop protection. Although of great interest, the atom- and step economic formation of the amide bond between a less nucleophilic aniline with an acid or ester remains still a major challenge. Herein, we report an aminolysis of aro...

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Main Authors: Niggli, Nadja Elena (Author) , Vollgraff, Tobias (Author) , Winter, Christian (Author) , Slavcheva Petkova, Desislava (Author) , Benson, Stefan (Author) , Götz, Roland (Author) , Hashmi, A. Stephen K. (Author) , Schaub, Thomas (Author)
Format: Article (Journal)
Language:English
Published: June 13, 2023
In: Advanced synthesis & catalysis
Year: 2023, Volume: 365, Issue: 11, Pages: 1794-1800
ISSN:1615-4169
DOI:10.1002/adsc.202300285
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/adsc.202300285
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.202300285
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Author Notes:Nadja E. Niggli, Tobias Vollgraff, Christian Winter, Desislava Slavcheva Petkova, Stefan Benson, Roland Götz, A. Stephen K. Hashmi and Thomas Schaub
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Summary:Anilides are often found in pharmaceuticals and active ingredients in crop protection. Although of great interest, the atom- and step economic formation of the amide bond between a less nucleophilic aniline with an acid or ester remains still a major challenge. Herein, we report an aminolysis of aromatic and alkyl esters with anilines catalyzed by a readily available catalytic system comprising of an earth-abundant Mn-salt in combination with an inexpensive base.
Item Description:Online veröffentlicht am 9. Mai 2023
Im Titel erscheint in der chemischen Formel die Ziffer 2 tiefgestellt
Gesehen am 07.12.2023
Physical Description:Online Resource
ISSN:1615-4169
DOI:10.1002/adsc.202300285

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